Observe Closely (1)pentobarbital will reduce the level or result of buprenorphine subdermal implant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Intently. Watch patients presently on buprenorphine subdermal implant who call for freshly-initiated remedy with CYP3A4 inducer for indications and signs or sympt
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